6/1/2023 0 Comments Pug template alter![]() ![]() Unexpectedly, we found that DNMT1 exhibits a strong and specific affinity for GU-rich RNAs that form a pUG-fold, a noncanonical In this study, we have confirmed that human DNMT1 indeed interacts with multiple RNAs, including its own nuclear A link between RNAĪnd chromatin-associated proteins has recently emerged, and several studies have shown that DNMT1 can be regulated by a variety DNMT1 is responsible for methylating newly replicatedĭNA, but the precise regulation of DNMT1 to ensure faithful DNA methylation remains poorly understood. Aberrant DNA methylation is one of the earliest hallmarks of cancer.
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